
location_on76, East Hillcrest Drive, Thousand Oaks, Ventura County, California, 91360, United States
At Amgen, you are part of something bigger. Our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, we have helped pioneer the world of biotech in our fight against the world's toughest diseases. With a focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. We are advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions.
As a member of the Amgen team, you will help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities that lie within them, you will thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
In this vital role, you will join our Drug Substance Technologies - Synthetics (DSTS) group at our Thousand Oaks campus. Amgen's DSTS group within Process Development is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance our exciting portfolio of synthetic and hybrid assets. Process chemists within our team apply their synthetic training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.
In this dynamic role, you will be responsible for developing innovative solutions to support chemical and bio-conjugation process development of our hybrid modality drug candidates, including antibody drug conjugates, peptide antibody conjugates, synthetic peptides, and/or oligonucleotides. The role includes providing technical expertise and translating developed processes toward manufacturing and commercialization. You will work effectively with a diverse team of synthetic chemists, chemical engineers, and analytical chemists to invent synthetic routes and develop safe, robust, sustainable, and cost-effective processes. Your work will drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides, while supporting cGMP manufacturing and technology transfer to internal and external facilities.
Amgen does not have a specific application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate. In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed, and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Skills: Organic Chemistry, Chemical Biology, Biochemistry, Antibody Drug Conjugate, Synthetic Oligonucleotide, Synthetic Peptide, Process Development, Bio-Conjugation, Hydrophobic Interaction Chromatography, HPLC.
Education: PhD in organic chemistry, chemical biology, or biochemistry preferred; Doctorate degree (PhD, PharmD, or MD) required; Master's degree with 3 years of scientific experience (alternative to PhD).
Work model: On-site
76, East Hillcrest Drive, Thousand Oaks, Ventura County, California, 91360, United States
Thousand Oaks, California
Ph.D. in organic chemistry, chemical biology or biochemistry with expertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development; Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry; Extensive hands-on expertise in the synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates and experience with bio-conjugation techniques; Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography-Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC; Familiarity with laboratory automation, data analysis and visualization techniques and tools; Track record of peer-reviewed publications and research presentations; Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results; Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects; A research summary included with CV.
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