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  1. Home
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  5. Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs
Amgen logo

Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

Not Disclosed•Full-TimeOn-site

location_on76, East Hillcrest Drive, Thousand Oaks, Ventura County, California, 91360, United States

Apply Now

Join Amgen's Mission of Serving Patients

At Amgen, you are part of something bigger. Our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, we have helped pioneer the world of biotech in our fight against the world's toughest diseases. With a focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. We are advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions.

As a member of the Amgen team, you will help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities that lie within them, you will thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

About the Role

In this vital role, you will join our Drug Substance Technologies - Synthetics (DSTS) group at our Thousand Oaks campus. Amgen's DSTS group within Process Development is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance our exciting portfolio of synthetic and hybrid assets. Process chemists within our team apply their synthetic training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.

In this dynamic role, you will be responsible for developing innovative solutions to support chemical and bio-conjugation process development of our hybrid modality drug candidates, including antibody drug conjugates, peptide antibody conjugates, synthetic peptides, and/or oligonucleotides. The role includes providing technical expertise and translating developed processes toward manufacturing and commercialization. You will work effectively with a diverse team of synthetic chemists, chemical engineers, and analytical chemists to invent synthetic routes and develop safe, robust, sustainable, and cost-effective processes. Your work will drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides, while supporting cGMP manufacturing and technology transfer to internal and external facilities.

Hiring Process

Amgen does not have a specific application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate. In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Our Culture and Commitment

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed, and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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Skills, education and keywords

Skills: Organic Chemistry, Chemical Biology, Biochemistry, Antibody Drug Conjugate, Synthetic Oligonucleotide, Synthetic Peptide, Process Development, Bio-Conjugation, Hydrophobic Interaction Chromatography, HPLC.

Education: PhD in organic chemistry, chemical biology, or biochemistry preferred; Doctorate degree (PhD, PharmD, or MD) required; Master's degree with 3 years of scientific experience (alternative to PhD).

Frequently asked questions about Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen

What does a Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen do?expand_more
In this Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen role, you will advance enabling technologies to accelerate pharmaceutical development and improve process sustainability and efficiency; contribute to drug substance development teams by providing experimental results, data interpretation, and technical documentation; work cross-functionally to deliver regulatory documents and support regulatory filings; and design and develop safe, robust, and cost-effective synthetic routes for antibody drug conjugates, peptides, and oligonucleotides.
What are the requirements for this Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs role?expand_more
To qualify for the Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen position, applicants should have: Doctorate degree PhD OR PharmD OR MD; Master's degree and 3 years of Scientific experience; Bachelor's degree and 5 years of Scientific experience; Ph.D. in organic chemistry, chemical biology or biochemistry; Post-doctoral experience; and Expertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development.
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Work location

Work model: On-site

location_on

76, East Hillcrest Drive, Thousand Oaks, Ventura County, California, 91360, United States

Thousand Oaks, California

Key Responsibilities

  • check_circleAdvance enabling technologies to accelerate pharmaceutical development and improve process sustainability and efficiency
  • check_circleContribute to drug substance development teams by providing experimental results, data interpretation, and technical documentation
  • check_circleWork cross-functionally to deliver regulatory documents and support regulatory filings
  • check_circleDesign and develop safe, robust, and cost-effective synthetic routes for antibody drug conjugates, peptides, and oligonucleotides
  • check_circleDrive technology innovation in the synthesis, purification, and characterization of bioconjugates and synthetic molecules
  • check_circleSupport cGMP manufacturing activities and manage technology transfer to internal and external manufacturing facilities
  • check_circleEnsure process performance through process understanding, modeling, and characterization techniques
  • check_circleServe as a technical expert in bioconjugation and process chemistry while keeping current with field advancements

Requirements

  • verifiedDoctorate degree PhD OR PharmD OR MD
  • verifiedMaster's degree and 3 years of Scientific experience
  • verifiedBachelor's degree and 5 years of Scientific experience
  • verifiedPh.D. in organic chemistry, chemical biology or biochemistry
  • verifiedPost-doctoral experience
  • verifiedExpertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development
  • verifiedHands-on expertise in synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates
  • verifiedExperience with bio-conjugation techniques
  • verifiedFamiliarity with laboratory automation, data analysis and visualization techniques

Nice to Have

Ph.D. in organic chemistry, chemical biology or biochemistry with expertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development; Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry; Extensive hands-on expertise in the synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates and experience with bio-conjugation techniques; Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography-Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC; Familiarity with laboratory automation, data analysis and visualization techniques and tools; Track record of peer-reviewed publications and research presentations; Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results; Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects; A research summary included with CV.

Benefits & Perks

check_circleRetirement and Savings Plan with generous company contributionscheck_circleGroup medical, dental, and vision coveragecheck_circleLife and disability insurancecheck_circleFlexible spending accountscheck_circleDiscretionary annual bonus programcheck_circleStock-based long-term incentivescheck_circleAward-winning time-off planscheck_circleFlexible work models where possible
Amgen logo
Company

Amgen

Industry

scientific & qa

View company profilearrow_forwardlanguageWebsite
Quick Overview

Experience

3+ yrs (Senior)

Education

PhD in organic chemistry, chemical biology, or biochemistry preferred

Job Type

Full-Time

Skills Required

Organic ChemistryChemical BiologyBiochemistryAntibody Drug ConjugateSynthetic OligonucleotideSynthetic PeptideProcess DevelopmentBio-ConjugationHydrophobic Interaction ChromatographyHPLC
$48k-61k
arrow_forward
Where is the Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs role at Amgen located?expand_more
Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen is based in 76, East Hillcrest Drive, Thousand Oaks, Ventura County, California, 91360, United States. This is a on-site role.
Is this Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs job remote, hybrid, or on-site?expand_more
Amgen has listed this Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs role as on-site.
How much experience is required for this Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs role?expand_more
Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen typically requires 3+ years of relevant experience at the senior level.
What skills do you need for the Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs role at Amgen?expand_more
Key skills for Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen include Organic Chemistry; Chemical Biology; Biochemistry; Antibody Drug Conjugate; Synthetic Oligonucleotide; Synthetic Peptide; Process Development; and Bio-Conjugation.
What education is required for Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen?expand_more
Educational requirements for this role: PhD in organic chemistry, chemical biology, or biochemistry preferred; Doctorate degree (PhD, PharmD, or MD) required; and Master's degree with 3 years of scientific experience (alternative to PhD).
What category does the Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs role belong to?expand_more
Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs at Amgen is part of the scientific & qa job category on Recrutus.
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