Senior Scientist I Computational Chemistry

About the Team

The Molecular Profiling and Drug Delivery (MPDD) function within the Synthetic Molecule CMC organization drives a broad range of deliverables across drug discovery and development. Our mission is to utilize state-of-the-art automation and computational tools, supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry, to collaboratively design and progress candidates with a higher probability of success. From virtual screening through clinical proof of concept and product launch, we work in cross-functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations. This ensures robust commercial processes and aligned control strategies across drug substance and product.

Within AbbVie's MPDD organization, computational chemists collaborate with Development Sciences and Discovery Sciences across two primary focus areas: molecular design and profiling, and formulation design across modalities. We guide the design and progression of compounds and formulations with optimal developability properties, advancing first-in-class and best-in-class clinical candidates. Our team is dedicated to developing hierarchical modeling approaches, including physics-based atomistic modeling (Molecular Dynamics and Quantum Mechanics), Machine Learning (ML)/Artificial Intelligence (AI), and hybrid Physics-ML/AI models. We seamlessly integrate these models into project screening funnels and the medicinal chemistry design cycle alongside medicinal chemists, data scientists, material scientists, and molecular modelers.

About the Role

AbbVie's MPDD organization is seeking a highly motivated, talented, and creative Senior Scientist to make key contributions toward enabling our modeling vision. In this role, you will work collaboratively with discovery colleagues to develop stage-appropriate computational models using advanced techniques to enable the design and optimization of drug candidates across modalities. You will serve as a lead computational scientist on project teams, driving the development and implementation of appropriate models to support various aspects of drug discovery and development. Your work will focus on advancing computational chemistry capabilities through the innovation and implementation of new methodologies and workflows to capture key developability properties such as permeability, stability, toxicity, and solubility. You will generate hypotheses for compound property improvement, apply them to new compound design, and contribute to the development of computational infrastructure by identifying novel tools and techniques. As a strong team player, you will promote a design-driven and predict-first culture while educating and training colleagues on various computational tools and techniques.

Equal Opportunity

AbbVie is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.