Principal Research Scientist II - Process Chemistry
Not Disclosed•Full-TimeOn-site
location_onLewis Avenue, North Chicago, Lake County, Illinois, 60088, United States
About the Team
The Process Chemistry group at AbbVie is dedicated to inventing and executing the chemical processes required to prepare active pharmaceutical ingredients (APIs). Our mission is to enable toxicology studies, clinical trials, and drug product development for AbbVie's pre-clinical and clinical candidates. Through the creation of valuable intellectual property in composition of matter, chemical processes, and technology, we drive the development of safe and cost-effective commercial manufacturing processes.
About the Role
We are seeking a highly skilled and innovative Principal Research Scientist II to lead the development of biocatalytic processes for the scalable synthesis of APIs. This role focuses on small molecules, peptides, antibody-drug conjugates, and other modalities. You will apply your expertise in biocatalysis to drive enzyme discovery, directed evolution campaigns, and the application of AI/ML tools for optimizing enzyme-catalyzed reactions.
In this position, you will serve as a technical leader within a matrixed team, setting strategies for solving complex synthetic problems and mentoring scientists. Your day-to-day work involves bridging the gap between unrelated concepts to generate new ideas, authoring technical reports and patents, and presenting findings at scientific forums. You will be expected to integrate modern computational and high-throughput experimentation tools into process development cycles to accelerate discovery and optimization.
Work location
Work model: On-site
Lewis Avenue, North Chicago, Lake County, Illinois, 60088, United States
North Chicago, Illinois
Key Responsibilities
- check_circleLead strategies for solving complex synthetic problems using biocatalytic methods
- check_circleDesign and engineer enzymes using recombinant DNA and directed evolution techniques
- check_circleLead project teams for process development of small molecules and antibody-drug conjugates
- check_circleAuthor and review technical reports, regulatory documents, patents, and scientific publications
- check_circleLeverage AI/ML tools and high-throughput experimentation to optimize enzyme screening
- check_circleManage a group of scientists by setting strategies, timelines, and providing mentorship
- check_circleEnsure adherence to GxP compliance, safety standards, and corporate codes of conduct
Requirements
- verifiedDeep expertise in biocatalysis
- verifiedStrong foundation in synthetic organic chemistry
- verifiedExperience with recombinant DNA techniques
- verifiedExperience with heterologous protein expression
- verifiedExperience with directed evolution methodologies
- verifiedProficiency in AI/ML tools
- verifiedProficiency in bioinformatics platforms
- verifiedExperience with high-throughput experimentation (HTE)
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Frequently asked questions about Principal Research Scientist II - Process Chemistry at AbbVie
What does a Principal Research Scientist II - Process Chemistry at AbbVie do?expand_more
A Principal Research Scientist II - Process Chemistry at AbbVie is responsible for the following: Lead strategies for solving complex synthetic problems using biocatalytic methods; Design and engineer enzymes using recombinant DNA and directed evolution techniques; Lead project teams for process development of small molecules and antibody-drug conjugates; and Author and review technical reports, regulatory documents, patents, and scientific publications.
What are the requirements for this Principal Research Scientist II - Process Chemistry role?expand_more
AbbVie is looking for candidates who meet the following requirements: Deep expertise in biocatalysis; Strong foundation in synthetic organic chemistry; Experience with recombinant DNA techniques; Experience with heterologous protein expression; Experience with directed evolution methodologies; and Proficiency in AI/ML tools.
Where is the Principal Research Scientist II - Process Chemistry role at AbbVie located?expand_more
Principal Research Scientist II - Process Chemistry at AbbVie is based in Lewis Avenue, North Chicago, Lake County, Illinois, 60088, United States. This is a on-site role.
Is this Principal Research Scientist II - Process Chemistry job remote, hybrid, or on-site?expand_more
AbbVie has listed this Principal Research Scientist II - Process Chemistry role as on-site.
How much experience is required for this Principal Research Scientist II - Process Chemistry role?expand_more
Candidates for Principal Research Scientist II - Process Chemistry at AbbVie should have lead.
What skills do you need for the Principal Research Scientist II - Process Chemistry role at AbbVie?expand_more
Key skills for Principal Research Scientist II - Process Chemistry at AbbVie include Biocatalysis; Synthetic Organic Chemistry; Ai/ml Tools; Bioinformatics; High-Throughput Experimentation; Recombinant Dna Techniques; Heterologous Protein Expression; and Directed Evolution.
What category does the Principal Research Scientist II - Process Chemistry role belong to?expand_more
Principal Research Scientist II - Process Chemistry at AbbVie is part of the scientific & qa job category on Recrutus.