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  1. Home
  2. chevron_right
  3. scientific & qa
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  5. Principal Research Scientist I (Analytical R&D for LNP and Small Molecule)
AbbVie logo

Principal Research Scientist I (Analytical R&D for LNP and Small Molecule)

Not Disclosed•Full-TimeHybrid

location_on26;28, Breeze Drive, Mill Street, Tatnuck Square, Worcester, Worcester County, Massachusetts, 01602, United States

Apply Now

About the Role

We are seeking a Principal Research Scientist I to serve as an Analytical Project Leader for New Chemical Entities (NCEs) in both drug substance and drug product, spanning preclinical and clinical programs. This role is designed for a highly motivated analytical scientist with a fit-for-purpose mindset and extensive expertise in R&D environments.

The successful candidate will conceive, execute, and communicate novel strategies to achieve project goals and department imperatives within a multi-disciplinary organization. You will manage CMC deliverables relevant to early-phase clinical development and discovery programs, fostering productive collaborations across the global Analytical R&D organization and with cross-functional partners including Discovery, Pre-Clinical Safety, Process Chemistry, Drug Delivery, and Quality Assurance.

Work Environment

This position is based at the AbbVie Bioresearch Center in Worcester, MA. The role requires a hybrid work model, with 50% on-site support at the Worcester location and 50% at the AbbVie Cambridge Crossing site in Cambridge, MA, adjusted according to project needs.

Culture & Values

We value scientific initiative and creativity, encouraging team members to raise the bar and remain unsatisfied with the status quo. In this role, you will embrace the ideas of others, nurture innovation, and manage the journey from concept to reality. A commitment to safety, quality, and regulatory compliance is essential to our operations.

Work location

Work model: Hybrid

location_on

26;28, Breeze Drive, Mill Street, Tatnuck Square, Worcester, Worcester County, Massachusetts, 01602, United States

Worcester, Massachusetts

Key Responsibilities

  • check_circleApply analytical separation and detection modes for complex impurity profiling of pharmaceutical products

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Frequently asked questions about Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie

What does a Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie do?expand_more
A Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie is responsible for the following: Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products; Generate new scientific proposals and lead those efforts to achieve project goals; Anticipate and evaluate scientific or regulatory advances to respond with appropriate strategies; and Manage CMC deliverables relevant to early-phase clinical development and discovery programs.
What are the requirements for this Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) role?expand_more
To qualify for the Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie position, applicants should have: Extensive expertise in R&D environment; Expertise with synthetic molecules in solid oral dosage forms; Experience as an analytical project lead; Experience managing CMC deliverables for early-phase clinical development; and Experience with pre-clinical candidate compounds.
Where is the Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) role at AbbVie located?expand_more
Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie is based in 26;28, Breeze Drive, Mill Street, Tatnuck Square, Worcester, Worcester County, Massachusetts, 01602, United States. This is a hybrid role.
bookmark
check_circle
Generate new scientific proposals and lead those efforts to achieve project goals
  • check_circleAnticipate and evaluate scientific or regulatory advances to respond with appropriate strategies
  • check_circleManage CMC deliverables relevant to early-phase clinical development and discovery programs
  • check_circleFoster productive collaborations within the global Analytical R&D organization and cross-functional partners
  • check_circleDemonstrate scientific initiative and creativity in research or development activities
  • check_circleEnsure compliance with AbbVie safety, quality, regulatory policies, and government regulations
  • check_circleManage innovation to reality by embracing ideas and nurturing new concepts
  • Requirements

    • verifiedExtensive expertise in R&D environment
    • verifiedExpertise with synthetic molecules in solid oral dosage forms
    • verifiedExperience as an analytical project lead
    • verifiedExperience managing CMC deliverables for early-phase clinical development
    • verifiedExperience with pre-clinical candidate compounds

    Nice to Have

    Additional experience with lipid nanoparticles.

    AbbVie logo
    Company

    AbbVie

    Industry

    scientific & qa

    View company profilearrow_forwardlanguageWebsite
    Quick Overview

    Experience

    Lead

    Job Type

    Full-Time

    Skills Required

    Analytical SeparationDetection ModesImpurity ProfilingSynthetic MoleculesSolid Oral Dosage FormsLipid NanoparticlesCMC DeliverablesPre-Clinical Candidate CompoundsEarly-Phase Clinical DevelopmentDiscovery Programs
    $69k-119karrow_forward
    Is this Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) job remote, hybrid, or on-site?
    expand_more
    AbbVie has listed this Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) role as hybrid.
    How much experience is required for this Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) role?expand_more
    Candidates for Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie should have lead.
    What skills do you need for the Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) role at AbbVie?expand_more
    Key skills for Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie include Analytical Separation; Detection Modes; Impurity Profiling; Synthetic Molecules; Solid Oral Dosage Forms; Lipid Nanoparticles; CMC Deliverables; and Pre-Clinical Candidate Compounds.
    What category does the Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) role belong to?expand_more
    Principal Research Scientist I (Analytical R&D for LNP and Small Molecule) at AbbVie is part of the scientific & qa job category on Recrutus.
    Recrutus

    Curating the world's most innovative career opportunities. We bridge the gap between visionary talent and industry-leading companies.

    Search roles by city, category, skill, or job type — explore verified US employers, salary benchmarks, and remote-friendly teams hiring nationwide.

    publiclanguageshare
    Job seekers
    Browse jobsCompanies hiringRemote jobsJobs by locationJobs by cityJobs by categoryJobs by skillCareer guidesCareer blogSalary insights
    Job types
    Contractor jobsFull-Time jobsIntern jobsOther jobsPart-Time jobsPer-Diem jobsTemporary jobsVolunteer jobs
    Top states
    Jobs in TexasJobs in CaliforniaJobs in New YorkJobs in FloridaJobs in North CarolinaJobs in VirginiaAll states →
    Top categories
    Healthcare & Nursing jobsLogistics & Warehouse jobsEngineering jobsIT jobsSales jobsHospitality & Catering jobsAccounting & Finance jobs
    Popular skills
    CDL A jobsExcel jobsEnglish jobsMicrosoft Office jobs
    Featured employers
    Company
    About usFAQContactPrivacy policy

    Recrutus helps candidates discover roles that match their skills and helps teams reach qualified applicants faster. Browse by metro, discipline, or work style — from internships to senior leadership.

    © 2026 Recrutus. All rights reserved.
    Terms of serviceCookie policyAcceptable useDMCA policyEmployer termsCandidate terms
    US privacy notice
    Accessibility