Director, Biology
Not Disclosed•Full-TimeHybrid
location_onBig Bully Turf, 350, Front Street, Banker's Hill, San Diego, San Diego County, California, 92101, United States
About Alterome
Redefining precision oncology, one alteration at a time. Alterome is a clinical-stage precision oncology company built on rigorous science and relentless execution. In four years, we have taken two internally discovered first-of-their-kind alteration-specific cancer therapies from idea to clinic, driven by a team that blends deep biology and chemistry expertise with advanced computational and physics-based drug design.
About the Role
As the Director, Biology, you will provide scientific and operational leadership for biology activities supporting assigned discovery and preclinical programs. This role is pivotal in leading the biology strategy from target validation through IND-enabling studies, with a strong emphasis on cross-functional integration and adaptable execution.
You will partner closely with Medicinal Chemistry, DMPK/PK, Toxicology, and Informatics teams to ensure that biology questions, study designs, and data outputs are clear, decision-enabling, and aligned with evolving program needs. Success in this position requires balancing scientific rigor with flexibility in workflows, enabling rapid learning and the efficient advancement of pipeline assets. You will lead a high-performing team, manage external academic and CRO partnerships, and influence investment decisions related to pipeline programs across all stages of development.
Culture & Location
We foster a phenomenal company culture characterized by openness to feedback, continuous improvement, and strong cross-functional partnership. Our office is centrally located in San Diego, CA, at the intersection of the 15 and 56 Freeways, featuring a full-service gym on-site with showers and towel service.
This is a hybrid role requiring three days per week in the office. We are currently not considering out-of-state candidates for this position.
Application Process
Candidates interested in joining our mission to redefine precision oncology should submit their application through our careers portal. We look for individuals who can translate complex biological concepts clearly to cross-functional and senior stakeholders while driving data-driven recommendations.
Work location
Work model: Hybrid
Big Bully Turf, 350, Front Street, Banker's Hill, San Diego, San Diego County, California, 92101, United States
San Diego, California
Key Responsibilities
- check_circleDefine and execute overarching biology strategy spanning target validation, disease biology, and IND-enabling studies
- check_circleOversee design, execution, and interpretation of complex biochemical, cellular, and in vivo studies
- check_circleProvide biological hypotheses and data interpretation to support program staging and gating decisions
- check_circleProvide biology leadership for IND enabling packages, regulatory interactions, and scientific submissions
- check_circleDevelop and manage key collaborations with CROs, academic labs, and industry partners to accelerate research
- check_circleOptimize the preclinical portfolio by evaluating new opportunities, competitive landscapes, and external science
- check_circleInterface with Medicinal Chemistry, DMPK/PK, and Toxicology teams to enable rapid crossfunctional decision-making
- check_circleLead, mentor, and develop scientists while fostering a culture of continuous improvement and collaboration
Requirements
- verifiedPh.D. or M.S. in biology, pharmacology, or related discipline
- verified10 years biotech/pharma experience for Ph.D. or 15 years for M.S.
- verifiedExperience advancing programs toward IND enablement
- verifiedExpertise in in-vitro/in-vivo pharmacology, mechanistic biology, target selection/validation, and translational research
- verifiedExperience managing scientific teams
- verifiedExperience working with Medicinal Chemistry and DMPK/PK teams
- verifiedExperience managing external collaborations and CROs
- verifiedOncology drug discovery experience preferred
- verifiedHybrid role requiring 3 days per week in San Diego, CA
Benefits & Perks
check_circleMedical, dental, and vision coveragecheck_circleLife insurancecheck_circle401k with company matchingcheck_circlePaid holidaysFlexible time off
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Skills, education and keywords
Skills: Biology, Pharmacology, Disease Biology, Translational Biology, Target Validation, Mechanistic Deconvolution, In-Vitro Pharmacology, In-Vivo Pharmacology, Mechanistic Biology, Target Selection.
Education: PhD in Biology required with 10 years experience; Master's in Biology required with 15 years experience.
Frequently asked questions about Director, Biology at Alterome Therapeutics, Inc
What does a Director, Biology at Alterome Therapeutics, Inc do?expand_more
Day-to-day, the Director, Biology at Alterome Therapeutics, Inc will define and execute overarching biology strategy spanning target validation, disease biology, and ind-enabling studies; oversee design, execution, and interpretation of complex biochemical, cellular, and in vivo studies; provide biological hypotheses and data interpretation to support program staging and gating decisions; and provide biology leadership for ind enabling packages, regulatory interactions, and scientific submissions.
What are the requirements for this Director, Biology role?expand_more
To qualify for the Director, Biology at Alterome Therapeutics, Inc position, applicants should have: Ph.D. or M.S. in biology, pharmacology, or related discipline; 10 years biotech/pharma experience for Ph.D. or 15 years for M.S.; Experience advancing programs toward IND enablement; Expertise in in-vitro/in-vivo pharmacology, mechanistic biology, target selection/validation, and translational research; Experience managing scientific teams; and Experience working with Medicinal Chemistry and DMPK/PK teams.
Where is the Director, Biology role at Alterome Therapeutics, Inc located?expand_more
Director, Biology at Alterome Therapeutics, Inc is based in Big Bully Turf, 350, Front Street, Banker's Hill, San Diego, San Diego County, California, 92101, United States. This is a hybrid role.
Is this Director, Biology job remote, hybrid, or on-site?expand_more
Alterome Therapeutics, Inc has listed this Director, Biology role as hybrid.
How much experience is required for this Director, Biology role?expand_more
Director, Biology at Alterome Therapeutics, Inc typically requires 10+ years of relevant experience at the executive level.
What skills do you need for the Director, Biology role at Alterome Therapeutics, Inc?expand_more
Key skills for Director, Biology at Alterome Therapeutics, Inc include Biology; Pharmacology; Disease Biology; Translational Biology; Target Validation; Mechanistic Deconvolution; In-Vitro Pharmacology; and In-Vivo Pharmacology.
What education is required for Director, Biology at Alterome Therapeutics, Inc?expand_more
Educational requirements for this role: PhD in Biology required with 10 years experience; and Master's in Biology required with 15 years experience.
What category does the Director, Biology role belong to?expand_more
Director, Biology at Alterome Therapeutics, Inc is part of the scientific & qa job category on Recrutus.
About Alterome Therapeutics, Inc
Alterome Therapeutics, Inc. is a clinical-stage precision oncology biotech developing alteration-specific therapeutics to address high value and validated oncogenic drivers. We are a team with expertise in multiple areas of science and operations, dedicated to co-elevating toward our vision to bring life-changing and life-saving therapies to cancer patients. We believe in our journey, in each other, and in our ability to collaboratively develop therapies that will help end cancers. Thus, we seek the best people for our company and provide the resources they need to grow, develop, and accomplish our collective goals. We are moving forward with humility & empathy, fearlessness & resilience, with a sense of inclusion & belonging, open communication and a deep trust. And…we manage to have a lot of fun along the way!
Browse more roles: All Alterome Therapeutics, Inc jobs, scientific & qa jobs on Recrutus.