Scientist, RNA Chemistry
Not Disclosed•Full-TimeOn-site
location_onWyman Street, Waltham, Middlesex County, Massachusetts, 02451, United States
About Dyne Therapeutics
Dyne Therapeutics is dedicated to delivering functional improvement for people living with genetically driven neuromuscular diseases. Our mission is to address the root cause of these conditions by developing therapeutics that target both muscle and the central nervous system (CNS). We are currently advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1), alongside preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.
At Dyne, we are driven by a commitment to impact individuals, families, and communities. Learn more at dyne-tx.com or follow us on X, LinkedIn, and Facebook.
About the Role
As a Scientist, RNA Chemistry on the Platform team, you will play a pivotal role in developing Dyne's oligonucleotide chemistry platform and supporting the discovery of novel nucleic acid therapeutics. This position is designed for an independent contributor who will execute the design, synthesis, purification, and analysis of oligonucleotides and their conjugates.
In this role, you will apply established methods to troubleshoot routine issues and leverage your technical expertise in modified RNA synthesis to produce high-quality oligonucleotides using state-of-the-art laboratory equipment. You will be responsible for optimizing synthesis methods, interpreting analytical data to improve purity and yields, and contributing to the rational design of oligonucleotides against various targets. This is a full-time, on-site position based in Waltham, MA.
Equal Opportunity
Dyne Therapeutics is an equal opportunity employer. We do not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
Work location
Work model: On-site
Wyman Street, Waltham, Middlesex County, Massachusetts, 02451, United States
Waltham, Massachusetts
Key Responsibilities
Similar Job Opportunities
Skills, education and keywords
Skills: Oligonucleotide Synthesis, Modified Rna Synthesis, Oligonucleotide Purification, HPLC, LCMS, Anion Exchange, Reverse Phase, Ip/rp, Iex, Sec.
Education: PhD in Chemistry or related scientific discipline.
Frequently asked questions about Scientist, RNA Chemistry at Dyne Therapeutics
What does a Scientist, RNA Chemistry at Dyne Therapeutics do?expand_more
Day-to-day, the Scientist, RNA Chemistry at Dyne Therapeutics will independently perform synthesis of modified rna oligonucleotides for in vitro and in vivo studies; troubleshoot and optimize synthesis methods to produce high quality oligonucleotides; interpret analytical data from hplc and lcms to improve purity and yields; and register synthesized oligonucleotides in the database and report experiments in the eln.
What are the requirements for this Scientist, RNA Chemistry role?expand_more
Dyne Therapeutics is looking for candidates who meet the following requirements: PhD in Chemistry or related scientific discipline with 2 years of experience; MSc with minimum 8 years of relevant industry experience in biotechnology or life sciences; Hands-on experience operating oligonucleotide synthesis and purification platforms (MerMade, K&A, AKTA Oligopilot); and Familiarity with biochemical and analytical assays for modified RNA oligonucleotides.
Where is the Scientist, RNA Chemistry role at Dyne Therapeutics located?expand_more
Scientist, RNA Chemistry at Dyne Therapeutics is based in Wyman Street, Waltham, Middlesex County, Massachusetts, 02451, United States. This is a on-site role.