Principal Investigator, Process Chemistry
Not Disclosed•Full-TimeOn-site
location_on37, East 13th Street, East Brandywine Historic District, Wilmington, New Castle County, Delaware, 19801, United States
About Incyte
Incyte is a biopharmaceutical company dedicated to the discovery, development, and commercialization of novel medicines to address serious unmet medical needs in oncology and inflammation and autoimmunity. We are committed to the rigorous pursuit of research and development excellence to improve patient lives, make a difference in healthcare, and build sustainable value. Our mission is to discover and develop first-in-class and best-in-class medicines, advancing a diverse portfolio of large and small molecules.
About the Role
As a Principal Investigator in Process Development, you will lead chemical process research and development efforts. This role is pivotal in bridging the gap between discovery and commercial manufacturing. You will manage High-Throughput Experimentation (HTE) center equipment, ensuring reliable daily operations and coordinating with vendors to minimize downtime. Your work will directly accelerate discovery programs by executing HTE experiments to identify optimal conditions and generating curated datasets to support predictive AI/ML models.
You will collaborate closely with Drug Discovery, medicinal chemistry, and internal/external Quality Control and Quality Assurance functions to ensure high-quality Active Pharmaceutical Ingredients (APIs) are manufactured and delivered on time. The role involves designing scalable synthetic routes, developing cost-effective chemical processes for late-stage candidates, and providing technical support to Contract Research Organizations (CROs) and Contract Manufacturing Organizations (CMOs) for commercial manufacturing processes. Additionally, you will author technology transfer documents, campaign summaries, and project progress reports, while providing input on new syntheses and optimized chemical processes.
Our Culture and Commitment
Incyte is committed to creating a diverse environment and is proud to be an equal opportunity employer. We believe that developing high-quality and cost-effective processes is essential to ensuring more medicines reach a diverse range of patients.
Application Process
By applying, you consent to Incyte processing your personal data to manage your job application and potentially enter into an employment relationship. During the hiring process, you may be asked to respond to questions to screen for objective criteria required by the job. You retain the right to access, delete, restrict, edit, move, or object to the use of your personal data, and you may report concerns to the relevant data privacy authority. For more details on data collection, usage, storage, and contact information for our Data Protection Officer, please refer to the privacy notice linked in the application portal.
Work location
Work model: On-site
37, East 13th Street, East Brandywine Historic District, Wilmington, New Castle County, Delaware, 19801, United States
Wilmington, Delaware
Key Responsibilities
- check_circleManage HTE Center equipment and coordinate with vendors to minimize downtime
- check_circleExecute HTE experiments to identify optimal conditions for drug candidates
- check_circleGenerate and curate HTE datasets to support predictive AI/ML model development
- check_circleDesign scalable synthetic routes for the manufacture of drug substances
- check_circleDevelop reliable and cost-effective chemical processes for late-stage drug candidates
- check_circleReview master batch production records for manufacturing drug substances under cGMP
- check_circleProvide technical support to CROs/CMOs to develop commercial manufacturing processes
- check_circleWrite technology transfer documents, campaign summaries, and project progress reports
- check_circleWork with CROs to design machinery and quality control instruments for API manufacturing
Requirements
- verifiedPh.D. in Synthetic Organic Chemistry
- verified3+ years industry HTE group experience
- verifiedMinimum of relevant pharmaceutical industrial experience involving chemical process research and development and/or medicinal chemistry
Skills, education and keywords
Skills: Hte, Ai, ML, CGM, Synthetic Organic Chemistry, Chemical Process Development, Api Manufacturing, Medicinal Chemistry, Hazard Analysis, Reaction Kinetics.
Education: Ph.D. in Synthetic Organic Chemistry required.
Frequently asked questions about Principal Investigator, Process Chemistry at Incyte
What does a Principal Investigator, Process Chemistry at Incyte do?expand_more
In this Principal Investigator, Process Chemistry at Incyte role, you will manage hte center equipment and coordinate with vendors to minimize downtime; execute hte experiments to identify optimal conditions for drug candidates; generate and curate hte datasets to support predictive ai/ml model development; and design scalable synthetic routes for the manufacture of drug substances.
What are the requirements for this Principal Investigator, Process Chemistry role?expand_more
Incyte is looking for candidates who meet the following requirements: Ph.D. in Synthetic Organic Chemistry; 3+ years industry HTE group experience; and Minimum of relevant pharmaceutical industrial experience involving chemical process research and development and/or medicinal chemistry.
Where is the Principal Investigator, Process Chemistry role at Incyte located?expand_more
Principal Investigator, Process Chemistry at Incyte is based in 37, East 13th Street, East Brandywine Historic District, Wilmington, New Castle County, Delaware, 19801, United States. This is a on-site role.
Is this Principal Investigator, Process Chemistry job remote, hybrid, or on-site?expand_more
Incyte has listed this Principal Investigator, Process Chemistry role as on-site.
How much experience is required for this Principal Investigator, Process Chemistry role?expand_more
Principal Investigator, Process Chemistry at Incyte typically requires 3+ years of relevant experience at the senior level.
What skills do you need for the Principal Investigator, Process Chemistry role at Incyte?expand_more
Key skills for Principal Investigator, Process Chemistry at Incyte include Hte; Ai; ML; CGM; Synthetic Organic Chemistry; Chemical Process Development; Api Manufacturing; and Medicinal Chemistry.
What education is required for Principal Investigator, Process Chemistry at Incyte?expand_more
Educational requirements for this role: Ph.D. in Synthetic Organic Chemistry required.
What category does the Principal Investigator, Process Chemistry role belong to?expand_more
Principal Investigator, Process Chemistry at Incyte is part of the scientific & qa job category on Recrutus.