Post-Doc Research Associate

About the Research Program

This position is part of an NIH-funded research program dedicated to studying the hepatic disposition of xenobiotics. The team utilizes in vitro model systems to investigate the regulation and trafficking of transport proteins, as well as the cellular and molecular mechanisms responsible for hepatic structure and function.

About the Role

You will investigate the utility of in vitro models—including hepatic organoid 3D cell models, sandwich-cultured hepatocytes, HuH-7 cells, and membrane vesicle systems—to predict the hepatic disposition of drugs and metabolites in vivo. Your work will focus on three key areas: predicting the impact of disease-mediated alterations in transport function on hepatocellular accumulation and excretion routes (canalicular vs. basolateral) of anionic drugs/metabolites, and examining hepatic transporter trafficking and regulatory mechanisms.

In this role, you will conduct a variety of experiments such as in vitro cell culture, transport assays, Western Blotting, cloning, mutagenesis, immunohistochemical imaging, live cell imaging, and LC-MS/MS. Additionally, you will be responsible for maintaining the laboratory's animal care and use and radiation safety records in strict accordance with institutional, state, and federal guidelines.

Application Instructions

Candidates with expertise in pharmacokinetic modeling, simulation, and drug-induced liver injury are preferred. Applicants must demonstrate experience with cell culture and advanced molecular biology/biochemistry techniques, along with excellent communication skills and the ability to work both independently and as part of an interdisciplinary team.