This Principal Scientist role within the Translational Medicine team at Nkarta focuses on advancing allogeneic natural killer cell therapies for autoimmune diseases. The position involves leading computational strategies for single-cell and spatial transcriptomics to drive biomarker discovery and mechanism-of-action investigations. Key responsibilities include developing scalable data pipelines, integrating multi-modal genomic datasets, and providing high-impact analyses that directly influence clinical decision-making. The role appeals to candidates seeking a hands-on leadership opportunity in a people-driven culture that values transparency, collaboration, and scientific innovation. Based in South San Francisco, the position offers hybrid work arrangements and the chance to contribute to a mission of making cell therapy more accessible to patients.